Molecular weight (DA)
95kD
Immunogen
Synthesized peptide derived from NVL . at AA range: 320-400
Specificity
NVL Polyclonal Antibody detects endogenous levels of NVL protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011],
Function
PTM:Phosphorylated.,similarity:Belongs to the AAA ATPase family.,tissue specificity:Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.,
Protein name
Nuclear valosin-containing protein-like
Other name
NVL; Nuclear valosin-containing protein-like; NVLp; Nuclear VCP-like protein
Fields
>>Ribosome biogenesis in eukaryotes
Human protein sequence Database
O15381
Mouse protein sequence database
Q9DBY8
Rat protein sequence database
Cellular localization
[Isoform 2]: Nucleus, nucleoplasm .; [Isoform 1]: Nucleus, nucleolus . Nucleus, nucleoplasm . Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. .
Tissue expression
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
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