Molecular weight (DA)
90kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CD36. AA range:331-380
Specificity
CD36 Polyclonal Antibody detects endogenous levels of CD36 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014],
Function
disease:Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.,disease:Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].,function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a
Protein name
Platelet glycoprotein 4
Other name
CD36; GP3B; GP4; Platelet glycoprotein 4; Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD36
Fields
>>PPAR signaling pathway;>>Phagosome;>>AMPK signaling pathway;>>ECM-receptor interaction;>>Hematopoietic cell lineage;>>Adipocytokine signaling pathway;>>Insulin resistance;>>Fat digestion and absorption;>>Cholesterol metabolism;>>Malaria;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis
Human protein sequence Database
P16671
Mouse protein sequence database
Q08857
Rat protein sequence database
Q07969
Cellular localization
Cell membrane ; Multi-pass membrane protein . Membrane raft . Golgi apparatus . Apical cell membrane . Upon ligand-binding, internalized through dynamin-dependent endocytosis. .
Tissue expression
Adipocyte,Liver,Mammary gland,Milk,Placenta,Platelet,Skeletal muscle,
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