Molecular weight (DA)
63kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 260-340
Specificity
AOAH Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010],
Function
catalytic activity:3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.,function:Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides.,PTM:Both subunits contain a number of cysteine residues that may form disulfide bridges.,similarity:Contains 1 saposin B-type domain.,subunit:Heterodimer.,
Protein name
Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit]
Human protein sequence Database
P28039
Mouse protein sequence database
O35298
Rat protein sequence database
Cellular localization
Secreted . Cytoplasmic vesicle . Detected in urine. .
Tissue expression
Pancreas,Synovial cell,
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