Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from the Internal region of human GABAA range: Rε.
Specificity
GABAA Rε Polyclonal Antibody detects endogenous levels of GABAA Rε protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008],
Function
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. Associates with alpha and beta subunits.,tissue specificity:Expressed in many tissues. Highest levels of expression in adult heart and placenta.,
Protein name
Gamma-aminobutyric acid receptor subunit epsilon
Other name
GABRE; Gamma-aminobutyric acid receptor subunit epsilon; GABA(A) receptor subunit epsilon
Fields
>>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction
Human protein sequence Database
P78334
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed in many tissues. Highest levels of expression in adult heart and placenta.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车