Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DP-1. AA range:361-410
Specificity
TFDP1 Polyclonal Antibody detects endogenous levels of TFDP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009],
Function
function:Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.,induction:Down-regulated during differentiation.,miscellaneous:E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP.,PTM:Phosphorylation by E2F-1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.,similarity:Belongs to the E2F/DP family.,subunit:Component of the E2F/DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact
Protein name
Transcription factor Dp-1
Other name
TFDP1; DP1; Transcription factor Dp-1; DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1
Fields
>>Cell cycle;>>TGF-beta signaling pathway
Human protein sequence Database
Q14186
Mouse protein sequence database
Q08639
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. .
Tissue expression
Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
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