Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 100-180
Specificity
NR4A2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
Function
developmental stage:Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.,function:Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the protein in the brain, indicates that it is not mandatorily associated with cell cycle progression.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.,
Gene Name
NR4A2 NOT NURR1 TINUR
Protein name
Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)
Fields
>>Aldosterone synthesis and secretion;>>Parathyroid hormone synthesis, secretion and action
Human protein sequence Database
P43354
Mouse protein sequence database
Q06219
Rat protein sequence database
Q07917
Cellular localization
Cytoplasm. Nucleus. Mostly nuclear; oxidative stress promotes cytoplasmic localization.
Tissue expression
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
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