Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SUH Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013],
Function
caution:Despite some similarity with the "phage" integrase family, it has no recombinase activity.,function:Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.,similarity:Belongs to the Su(H) family.,similarity:Contains 1 IPT/TIG domain.,subunit:Interacts with activated NOTCH1,
Gene Name
RBPJ IGKJRB IGKJRB1 RBPJK RBPSUH
Protein name
Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)
Fields
>>Notch signaling pathway;>>Th1 and Th2 cell differentiation;>>Spinocerebellar ataxia;>>Human papillomavirus infection;>>Epstein-Barr virus infection;>>Viral carcinogenesis
Human protein sequence Database
Q06330
Mouse protein sequence database
P31266
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Tissue expression
Eye,Placenta,Renal cell carcinoma,T
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