Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IL-5. AA range:43-92
Specificity
IL-5 Polyclonal Antibody detects endogenous levels of IL-5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013],
Function
function:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.,online information:Interleukin-5 entry,similarity:Belongs to the IL-5 family.,subunit:Homodimer; disulfide-linked.,
Protein name
Interleukin-5
Other name
IL5; Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Intestinal immune network for IgA production;>>Pathways in cancer;>>Asthma;>>Autoimmune thyroid disease;>>Inflammatory bowel disease;>>Allograft rejection
Human protein sequence Database
P05113
Mouse protein sequence database
P04401
Rat protein sequence database
Q08125
Cellular localization
Secreted.
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