Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human HOXD3. AA range:211-260
Specificity
HoxD3 Polyclonal Antibody detects endogenous levels of HoxD3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008],
Function
caution:It is uncertain whether Met-1 or Met-17 is the initiator.,function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.,similarity:Belongs to the Antp homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
Protein name
Homeobox protein Hox-D3
Other name
HOXD3; HOX1D; HOX4A; Homeobox protein Hox-D3; Homeobox protein Hox-4A
Human protein sequence Database
P31249
Mouse protein sequence database
P09027
Rat protein sequence database
P18867
Cellular localization
Nucleus.
Tissue expression
Brain,Lung,
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