Molecular weight (DA)
120kD
Immunogen
The antiserum was produced against synthesized peptide derived from human AOX1. AA range:521-570
Specificity
AOX1 Polyclonal Antibody detects endogenous levels of AOX1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008],
Function
catalytic activity:An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2).,caution:Was originally (PubMed:8248161) thought to be a xanthine dehydrogenase.,cofactor:Binds 2 2Fe-2S clusters.,cofactor:FAD.,cofactor:Molybdopterin.,similarity:Belongs to the xanthine dehydrogenase family.,similarity:Contains 1 2Fe-2S ferredoxin-type domain.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Homodimer.,tissue specificity:Abundant in liver, lower levels in lung, skeletal muscle, pancreas. Undetected in heart, brain and kidney.,
Protein name
Aldehyde oxidase
Other name
AOX1; AO; Aldehyde oxidase
Fields
>>Valine, leucine and isoleucine degradation;>>Tyrosine metabolism;>>Tryptophan metabolism;>>Vitamin B6 metabolism;>>Nicotinate and nicotinamide metabolism;>>Retinol metabolism;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>JAK-STAT signaling pathway
Human protein sequence Database
Q06278
Mouse protein sequence database
O54754
Rat protein sequence database
Q9Z0U5
Cellular localization
Cytoplasm .
Tissue expression
Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
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