Molecular weight (DA)
35kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 280-360
Specificity
MC3R Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008],
Function
function:Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.,polymorphism:Genetic variations in MC3R define the body mass index quantitative trait locus 9 (BMIQ9) [MIM:602025]. Variance in body mass index is a susceptibility factor for obesity.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Brain, placental, and gut tissues.,
Protein name
Melanocortin receptor 3 (MC3-R)
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P41968
Mouse protein sequence database
P33033
Rat protein sequence database
P32244
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Brain, placental, and gut tissues.
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