Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human FCGR2B/C. AA range:141-190
Specificity
CD32-B/C Polyclonal Antibody detects endogenous levels of CD32-B/C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Function
immune response,
Protein name
Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c
Other name
FCGR2B; CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD32; FCGR2C; CD32; FCG2; IGFR2;Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD32
Fields
>>Phagosome;>>Osteoclast differentiation;>>B cell receptor signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Measles
Human protein sequence Database
P31994
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane; Single-pass type I membrane protein.
Tissue expression
Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
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