Molecular weight (DA)
122kD
Immunogen
Synthesized peptide derived from the N-terminal region of human UBE4A.
Specificity
UBE4A Polyclonal Antibody detects endogenous levels of UBE4A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011],
Function
function:Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the ubiquitin conjugation factor E4 family.,similarity:Contains 1 U-box domain.,
Protein name
Ubiquitin conjugation factor E4 A
Other name
UBE4A; KIAA0126; Ubiquitin conjugation factor E4 A
Fields
>>Ubiquitin mediated proteolysis
Human protein sequence Database
Q14139
Mouse protein sequence database
Rat protein sequence database
Q6P7A2
Cellular localization
Cytoplasm .
Tissue expression
Bone marrow,Platelet,Skeletal muscle,
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