Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PPM1L. AA range:119-168
Specificity
PP2Cε Polyclonal Antibody detects endogenous levels of PP2Cε protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
Function
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5.,tissue specificity:Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.,
Protein name
Protein phosphatase 1L
Other name
PPM1L; PP2CE; Protein phosphatase 1L; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon
Human protein sequence Database
Q5SGD2
Mouse protein sequence database
Q8BHN0
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein .
Tissue expression
Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.
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