Molecular weight (DA)
26kD
Immunogen
Synthesized peptide derived from TREM-1 . at AA range: 40-120
Specificity
TREM-1 Polyclonal Antibody detects endogenous levels of TREM-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:100-500;IF/ICC 1:100-500;ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
triggering receptor expressed on myeloid cells 1(TREM1) Homo sapiens This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011],
Function
function:Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.,induction:Up-regulated by bacteria, fungi and lipopolysaccharides (LPS).,PTM:Glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with TYROBP/DAP12.,tissue specificity:Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hema
Protein name
Triggering receptor expressed on myeloid cells 1
Other name
TREM1; Triggering receptor expressed on myeloid cells 1; TREM-1; Triggering receptor expressed on monocytes 1; CD354
Human protein sequence Database
Q9NP99
Mouse protein sequence database
Q9JKE2
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Recruited to lipid rafts when activated. .; [Isoform 2]: Secreted .
Tissue expression
Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells (PubMed:10799849). Expression is associated with a mature stage of myeloid development (PubMed:11922939). Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.
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