Molecular weight (DA)
98kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 220-300
Specificity
LPIN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008],
Function
disease:Defects in LPIN2 are the cause of Majeed syndrome [MIM:609628]. Majeed syndrome is an autosomal recessive disorder combining features of chronic recurrent multifocal osteomyelitis [MIM:259680], congenital dyserythropoietic anemia and inflammatory dermatosis.,online information:Repertory of FMF and hereditary autoinflammatory disorders mutations,similarity:Belongs to the lipin family.,tissue specificity:Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.,
Protein name
Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2)
Fields
>>Glycerolipid metabolism;>>Glycerophospholipid metabolism;>>Metabolic pathways;>>mTOR signaling pathway;>>Alcoholic liver disease
Human protein sequence Database
Q92539
Mouse protein sequence database
Q99PI5
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm, cytosol . Endoplasmic reticulum membrane . Translocates to endoplasmic reticulum membrane with increasing levels of oleate. .
Tissue expression
Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
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