Molecular weight (DA)
90kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MCM5. AA range:21-70
Specificity
CDC46 Polyclonal Antibody detects endogenous levels of CDC46 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,
Protein name
DNA replication licensing factor MCM5
Other name
MCM5; CDC46; DNA replication licensing factor MCM5; CDC46 homolog; P1-CDC46
Fields
>>DNA replication;>>Cell cycle
Human protein sequence Database
P33992
Mouse protein sequence database
P49718
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Cytoplasm, cytosol . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
Tissue expression
Cervix,Cervix carcinoma,Lymph,Placenta,Spleen,Thymus,Tongue
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