Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human ART1. AA range:51-100
Specificity
CD296 Polyclonal Antibody detects endogenous levels of CD296 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008],
Function
catalytic activity:NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.,catalytic activity:NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.,similarity:Belongs to the Arg-specific ADP-ribosyltransferase family.,
Protein name
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Other name
ART1; GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; ADP-ribosyltransferase C2 and C3 toxin-like 1; ARTC1; Mono(ADP-ribosyl)transferase 1; CD296
Human protein sequence Database
P52961
Mouse protein sequence database
Q60935
Rat protein sequence database
Cellular localization
Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
Tissue expression
Skeletal muscle,
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