Molecular weight (DA)
98kD
Immunogen
The antiserum was produced against synthesized peptide derived from human EMR1. AA range:818-867
Specificity
EMR1 Polyclonal Antibody detects endogenous levels of EMR1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Function
alternative products:Comment=Additional isoforms seem to exist,function:Could be involved in cell-cell interactions.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 6 EGF-like domains.,tissue specificity:Wide expression; increased levels in peripheral blood mononuclear cells.,
Protein name
EGF-like module-containing mucin-like hormone receptor-like 1
Other name
EMR1; TM7LN3; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-like module receptor 1; EMR1 hormone receptor
Human protein sequence Database
Q14246
Mouse protein sequence database
Q61549
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Expression is restricted to eosinophils.
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