Molecular weight (DA)
97kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MER/SKY. AA range:716-765
Specificity
MerTK/Tyro3 Polyclonal Antibody detects endogenous levels of MerTK/Tyro3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:In case of filovirus infection, seems to function as a cell entry factor.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (imm
Protein name
Tyrosine-protein kinase Mer/Tyrosine-protein kinase receptor TYRO3
Other name
MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; TYRO3; BYK; DTK; RSE; SKY; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kin
Human protein sequence Database
Q12866/Q06418
Mouse gene ID
17289/22174
Mouse protein sequence database
Rat protein sequence database
P57097/P55146
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
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