Molecular weight (DA)
38kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR100. AA range:321-370
Specificity
GPR100 Polyclonal Antibody detects endogenous levels of GPR100 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008],
Function
function:Receptor for relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon.,
Protein name
Relaxin-3 receptor 2
Other name
RXFP4; GPR100; RLN3R2; Relaxin-3 receptor 2; RLN3 receptor 2; G-protein coupled receptor 100; G-protein coupled receptor GPCR142; Insulin-like peptide INSL5 receptor; Relaxin family peptide receptor 4
Fields
>>Neuroactive ligand-receptor interaction;>>Relaxin signaling pathway
Human protein sequence Database
Q8TDU9
Mouse protein sequence database
Q7TQP4
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon.
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