Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARSD. AA range:331-380
Specificity
Arylsulfatase D Polyclonal Antibody detects endogenous levels of Arylsulfatase D protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011],
Function
cofactor:Binds 1 calcium ion per subunit.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,tissue specificity:Expressed in the pancreas, kidney, liver, lung, placenta, brain and heart.,
Protein name
Arylsulfatase D
Abbreviation
Arylsulfatase D
Other name
ARSD; Arylsulfatase D; ASD
Human protein sequence Database
P51689
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Lysosome .
Tissue expression
Expressed in the pancreas, kidney, liver, lung, placenta, brain and heart.
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