Molecular weight (DA)
53kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 91-140
Specificity
THNS2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],
Function
cofactor:Pyridoxal phosphate.,function:Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.,similarity:Belongs to the serine/threonine dehydratase family.,
Protein name
Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT)
Human protein sequence Database
Q86YJ6
Mouse protein sequence database
Q80W22
Rat protein sequence database
Q5M7T9
Cellular localization
[Isoform SOFAT]: Secreted. Secreted by activated T-cells via a calcineurin-independent pathway.
Tissue expression
Brain,Colon,Ovarian carcinoma,Skin,Tongue,
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