Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from human HXA10
Specificity
This antibody detects endogenous levels of human HXA10
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011],
Function
function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.,similarity:Belongs to the Abd-B homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
Other name
Homeobox protein Hox-A10 (Homeobox protein Hox-1.8;Homeobox protein Hox-1H;PL)
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
P31260
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Caudate nucleus,Kidney,Muscle,Salivary gland,
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