Molecular weight (DA)
39kD
Immunogen
The antiserum was produced against synthesized peptide derived from human AIM2. AA range:51-100
Specificity
AIM2 Polyclonal Antibody detects endogenous levels of AIM2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008],
Function
disease:Defects in AIM2 may be a cause of microsatellite unstable colon cancers.,function:Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.,induction:By interferon gamma.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 HIN-200 domain.,subunit:Homodimer.,tissue specificity:Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.,
Protein name
Interferon-inducible protein AIM2
Other name
AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2
Fields
>>NOD-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway
Human protein sequence Database
O14862
Mouse protein sequence database
Q91VJ1
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Tissue expression
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
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