Molecular weight (DA)
36kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TLX1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010],
Function
disease:A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.,function:Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.,miscellaneous:TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.,similarity:Contains 1 homeobox DNA-binding domain.,
Gene Name
TLX1 HOX11 TCL3
Protein name
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
P31314
Mouse protein sequence database
P43345
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Pooled,
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