Immunogen
Synthetic peptide from human protein at AA range: 10-50
Specificity
The antibody detects endogenous FSHβ
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
follicle stimulating hormone beta subunit(FSHB) Homo sapiens The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
Function
disease:Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men.,function:Stimulates development of follicle and spermatogenesis in the reproductive organs.,online information:Follicle-stimulating hormone entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogona
Protein name
Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain)
Other name
Follitropin subunit beta (Follicle-stimulating hormone beta subunit;FSH-B;FSH-beta;Follitropin beta chain)
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>GnRH signaling pathway;>>Ovarian steroidogenesis
Human protein sequence Database
P01225
Mouse protein sequence database
Q60687
Rat protein sequence database
P18427
Cellular localization
Secreted . Efficient secretion requires dimerization with CGA. .
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