Molecular weight (DA)
60kD
Immunogen
Synthetic Peptide of Kv10.2 AA range: 264-314
Specificity
Kv10.2 protein(A260) detects endogenous levels of Kv10.2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.,sequence caution:Translated as Gly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG.,tiss
Protein name
Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (hEAG2) (Voltage-gated potassium channel subunit Kv10.2)
Other name
Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2;hEAG2;Voltage-gated potassium channel subunit Kv10.2)
Human protein sequence Database
Q8NCM2
Mouse protein sequence database
Q920E3
Rat protein sequence database
Q9EPI9
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.
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