Molecular weight (DA)
66kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TOR1AIP1. AA range:431-480
Specificity
LAP1B Polyclonal Antibody detects endogenous levels of LAP1B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016],
Function
function:Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TOR1AIP family.,subunit:Interacts with TOR1A.,
Protein name
Torsin-1A-interacting protein 1
Other name
TOR1AIP1; Torsin-1A-interacting protein 1; Lamin-associated protein 1B; LAP1B
Human protein sequence Database
Q5JTV8
Mouse protein sequence database
Q921T2
Rat protein sequence database
Cellular localization
Nucleus inner membrane ; Single-pass membrane protein .
Tissue expression
Expressed in muscle, liver and kidney.
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