Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
T2R50 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008],
Function
function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.,
Protein name
Taste receptor type 2 member 50 (T2R50) (Taste receptor type 2 member 51) (T2R51)
Fields
>>Taste transduction
Human protein sequence Database
P59544
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
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