Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 440-520
Specificity
BMPER Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011],
Function
function:Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.,similarity:Contains 1 TIL (trypsin inhibitory-like) domain.,similarity:Contains 1 VWFD domain.,similarity:Contains 5 VWFC domains.,subunit:Interacts with BMP4.,tissue specificity:Highly expressed in lung, and brain and also in primary chondrocytes.,
Protein name
BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2)
Human protein sequence Database
Q8N8U9
Mouse protein sequence database
Q8CJ69
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Highly expressed in lung, and brain and also in primary chondrocytes.
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