Molecular weight (DA)
49kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TBA8 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TUBA8 encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. TUBA8 (Tubulin Alpha 8) is a Protein Coding gene. Diseases associated with TUBA8 include Cortical Dysplasia, Complex, With Other Brain Malformations 8 and Optic Nerve Hypoplasia. Among its related pathways are Development Slit-Robo signaling and Cytoskeleton remodeling Neurofilaments.
Function
protein complex assembly, microtubule-based process, microtubule-based movement, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, cellular protein complex assembly, macromolecular complex subunit organization, protein polymerization, macromolecular complex assembly, protein complex biogenesis,
Protein name
Tubulin alpha-8 chain (Alpha-tubulin 8) (Tubulin alpha chain-like 2)
Fields
>>Phagosome;>>Apoptosis;>>Tight junction;>>Gap junction;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Salmonella infection
Human protein sequence Database
Q9NY65
Mouse protein sequence database
Q9JJZ2
Rat protein sequence database
Q6AY56
Cellular localization
Cytoplasm, cytoskeleton.
Tissue expression
Preferentially expressed in heart, skeletal muscle and testis. Expressed at low levels in the developing brain.
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