Molecular weight (DA)
34kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CREM. AA range:81-130
Specificity
CREM Polyclonal Antibody detects endogenous levels of CREM protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cAMP responsive element modulator(CREM) Homo sapiens This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.,PTM:Stimulated by phosphorylation.,sequence caution:Translated as Tyr.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Binds DNA as a dimer. Interacts with FHL5.,tissue specificity:Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.,
Protein name
cAMP-responsive element modulator
Other name
CREM; cAMP-responsive element modulator; Inducible cAMP early repressor; ICER
Fields
>>Adrenergic signaling in cardiomyocytes
Human protein sequence Database
Q03060
Mouse protein sequence database
P27699
Rat protein sequence database
Q03061
Cellular localization
Nucleus.; [Isoform 6]: Cytoplasm . Nucleus .
Tissue expression
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
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