Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Retinoid X Receptor gamma. AA range:171-220
Specificity
RXRγ Polyclonal Antibody detects endogenous levels of RXRγ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,
Protein name
Retinoic acid receptor RXR-gamma
Other name
RXRG; NR2B3; Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma
Fields
>>PPAR signaling pathway;>>Th17 cell differentiation;>>Thyroid hormone signaling pathway;>>Adipocytokine signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Chemical carcinogenesis - receptor activation;>>Thyroid cancer;>>Small cell lung cancer;>>Non-small cell lung cancer;>>Gastric cancer;>>Lipid and atherosclerosis
Human protein sequence Database
P48443
Mouse protein sequence database
P28705
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Expressed in aortic endothelial cells (at protein level).
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