Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
GBP2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013],
Function
function:Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product.,induction:By interferon gamma during macrophage activation.,similarity:Belongs to the GBP family.,
Protein name
Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2)
Fields
>>NOD-like receptor signaling pathway
Human protein sequence Database
P32456
Mouse protein sequence database
Q9Z0E6
Rat protein sequence database
Q63663
Cellular localization
Cytoplasm . Cytoplasm, perinuclear region . Golgi apparatus membrane . Membrane; Lipid-anchor . Cytoplasmic vesicle . GBP2-GBP5 dimers localize to the Golgi apparatus. .
Tissue expression
Foreskin,Lung,Skin,Spinal cord,Thymus,
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