Immunogen
The antiserum was produced against synthesized peptide derived from human MTR1A. AA range:191-240
Specificity
MEL-1A-R Polyclonal Antibody detects endogenous levels of MEL-1A-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008],
Function
function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.,
Protein name
Melatonin receptor type 1A
Other name
MTNR1A; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor
Fields
>>Neuroactive ligand-receptor interaction;>>Circadian entrainment
Human protein sequence Database
P48039
Mouse protein sequence database
Q61184
Rat protein sequence database
P49218
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
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