Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TBR1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015],
Function
function:Probable transcriptional regulator involved in developmental processes. TBR1 is required for normal brain development.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Brain.,
Protein name
T-box brain protein 1 (T-brain-1) (TBR-1) (TES-56)
Human protein sequence Database
Q16650
Mouse protein sequence database
Q64336
Rat protein sequence database
Cellular localization
Nucleus .
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