Molecular weight (DA)
150kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TNKS1BP1. AA range:1601-1650
Specificity
TAB182 Polyclonal Antibody detects endogenous levels of TAB182 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
PTM:ADP-ribosylated by TNKS1 (in vitro).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.,subunit:Binds to the ANK repeat domain of TNKS1 and TNKS2.,tissue specificity:Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.,
Function
PTM:ADP-ribosylated by TNKS1 (in vitro).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.,subunit:Binds to the ANK repeat domain of TNKS1 and TNKS2.,tissue specificity:Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.,
Protein name
182 kDa tankyrase-1-binding protein
Other name
TNKS1BP1; KIAA1741; TAB182; 182 kDa tankyrase-1-binding protein
Human protein sequence Database
Q9C0C2
Mouse protein sequence database
P58871
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm, cytoskeleton. Chromosome. Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.
Tissue expression
Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.
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