Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human WASF3. AA range:151-200
Specificity
WAVE3 Polyclonal Antibody detects endogenous levels of WAVE3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014],
Function
domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subunit:Binds actin and the Arp2/3 complex.,tissue specificity:Expressed in ovary and brain.,
Protein name
Wiskott-Aldrich syndrome protein family member 3
Other name
WASF3; KIAA0900; SCAR3; WAVE3; Wiskott-Aldrich syndrome protein family member 3; WASP family protein member 3; Protein WAVE-3; Verprolin homology domain-containing protein 3
Fields
>>Adherens junction;>>Fc gamma R-mediated phagocytosis;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Choline metabolism in cancer
Human protein sequence Database
Q9UPY6
Mouse protein sequence database
Q8VHI6
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton.
Tissue expression
Expressed in ovary and brain.
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