Molecular weight (DA)
112-130kD
Immunogen
Synthesized peptide derived from human GM130
Specificity
This antibody detects endogenous levels of human GM130
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010],
Function
domain:Extended rod-like protein with coiled-coil domains.,function:Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.,sequence caution:Sequence differs from that shown after position 814 due to an internal deletion.,similarity:Belongs to the GOLGA2 family.,subunit:Part of a larger oligomeric complex. Interacts with p115 (By similarity). Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.,
Other name
Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein;GM130;GM130 autoantigen;Golgin-95)
Human protein sequence Database
Q08379
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton, spindle pole . Associates with the mitotic spindle during mitosis (PubMed:26165940). .
Tissue expression
Brain,Cervix,Colon adenocarcinoma,Epithelium,Heart,Hepatocyte,Liver,Placenta,Thymus,
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