Molecular weight (DA)
22kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 40-120
Specificity
RAB13 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013],
Function
function:Could participate in polarized transport, in the assembly and/or the activity of tight junctions.,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions.,tissue specificity:Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.,
Protein name
Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)
Human protein sequence Database
P51153
Mouse protein sequence database
Q9DD03
Rat protein sequence database
P35286
Cellular localization
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Cell junction, tight junction . Golgi apparatus, trans-Golgi network membrane . Recycling endosome membrane . Cell projection, lamellipodium . Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). .
Tissue expression
Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.
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