Molecular weight (DA)
22kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 70-150
Specificity
IFNK Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008],
Function
function:May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.,induction:By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.,similarity:Belongs to the alpha/beta interferon family.,tissue specificity:Expressed in keratinocytes, monocytes and in resting dendritic cells.,
Gene Name
IFNK UNQ6124/PRO20084
Protein name
Interferon kappa (IFN-kappa)
Fields
>>Cytokine-cytokine receptor interaction;>>RIG-I-like receptor signaling pathway;>>JAK-STAT signaling pathway
Human protein sequence Database
Q9P0W0
Mouse protein sequence database
Q7TSL0
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in keratinocytes, monocytes and in resting dendritic cells.
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