Molecular weight (DA)
308kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1860-1940
Specificity
MAP1A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008],
Function
domain:The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.,function:Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.,PTM:LC2 is generated from MAP1A by proteolytic processing.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAP1 family.,subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4.,tissue specificity:Brain.,
Protein name
Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]
Fields
>>Viral life cycle - HIV-1
Human protein sequence Database
P78559
Mouse protein sequence database
Q9QYR6
Rat protein sequence database
P34926
Cellular localization
Cytoplasm, cytoskeleton .
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