Molecular weight (DA)
41kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SEPT3. AA range:136-185
Specificity
Septin 3 Polyclonal Antibody detects endogenous levels of Septin 3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
septin 3(SEPT3) Homo sapiens This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
function:Involved in cytokinesis .,induction:Up-regulated during neuronal differentiation.,PTM:Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91.,similarity:Belongs to the septin family.,subcellular location:Localizes in synaptosomes at dendritic synapses of neurons. Localizes within presynaptic terminals of neurons.,subunit:May assemble into a multicomponent structure.,tissue specificity:Brain specific.,
Protein name
Neuronal-specific septin-3
Other name
SEPT3; SEP3; Neuronal-specific septin-3
Fields
>>Bacterial invasion of epithelial cells;>>Shigellosis
Human protein sequence Database
Q9UH03
Mouse protein sequence database
Q9Z1S5
Rat protein sequence database
Q9WU34
Cellular localization
Cytoplasm. Cytoplasm, cytoskeleton . Cell junction, synapse .
Tissue expression
Brain-specific.
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