Molecular weight (DA)
14kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SF3B14. AA range:76-125
Specificity
SAP 14 Polyclonal Antibody detects endogenous levels of SAP 14 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008],
Function
function:Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with SF3B1/SF3b155 in the region of amino acids 255-424. Interacts to a lesser extent with SF3b130.,
Protein name
Pre-mRNA branch site protein p14
Other name
SF3B14; CGI-110; HSPC175; HT006; Pre-mRNA branch site protein p14; SF3b 14 kDa subunit
Human protein sequence Database
Q9Y3B4
Mouse protein sequence database
P59708
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Hypothalamus,Testis,Umbilical cord blood,Uterus,
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