Molecular weight (DA)
53kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PDE7A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011],
Function
catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,cofactor:Divalent cations.,developmental stage:Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.,domain:Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.,enzyme regulation:Insensitive to all selective PDE inhibitors.,function:Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase is highly specific for cAMP and may have a role in muscle signal transduction.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subcellular location:PDE7A1 (57 kDa) i
Protein name
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22)
Fields
>>Purine metabolism;>>Metabolic pathways;>>Morphine addiction
Human protein sequence Database
Q13946
Mouse protein sequence database
P70453
Rat protein sequence database
O08593
Cellular localization
[Isoform PDE7A1]: Cytoplasm, cytosol . PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. .; [Isoform PDE7A2]: Cytoplasm . PDE7A2 (50 kDa) is located to particulate cellular fractions. .
Tissue expression
[Isoform PDE7A1]: Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart (PubMed:9195912). It is expressed as well in two T-cell lines (PubMed:9195912). ; [Isoform PDE7A2]: Found abundantly in skeletal muscle and at low levels in heart.
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