Molecular weight (DA)
184kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CMTA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
disease:Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.,function:Transcriptional activator. May act as a tumor suppressor.,induction:Detected at low levels at interphase and in resting cells. Up-regulated during S-phase and mitosis. Levels decrease at the end of mitosis.,similarity:Belongs to the CAMTA family.,similarity:Contains 1 CG-1 DNA-binding domain.,similarity:Contains 1 IPT/TIG domain.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 IQ domains.,subunit:May interact with calmodulin .,tissue specificity:Detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen, heart and kidney. Detected in neuroblastic-type cultured neuroblastoma cells.,
Function
disease:Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.,function:Transcriptional activator. May act as a tumor suppressor.,induction:Detected at low levels at interphase and in resting cells. Up-regulated during S-phase and mitosis. Levels decrease at the end of mitosis.,similarity:Belongs to the CAMTA family.,similarity:Contains 1 CG-1 DNA-binding domain.,similarity:Contains 1 IPT/TIG domain.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 IQ domains.,subunit:May interact with calmodulin .,tissue specificity:Detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen, heart and kidney. Detected in neuroblastic-type cultured neuroblastoma cells.,
Gene Name
CAMTA1 KIAA0833 MSTP023
Protein name
Calmodulin-binding transcription activator 1
Human protein sequence Database
Q9Y6Y1
Mouse protein sequence database
A2A891
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.
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