Molecular weight (DA)
15kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
LSHB Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008],
Function
disease:Defects in LHB are a cause of hypogonadism [MIM:152780]. Hypogonadism is characterized by infertility and pseudohermaphroditism.,function:Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.,online information:Luteinizing hormone entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,tissue specificity:Pituitary gland.,
Protein name
Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta)
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Prolactin signaling pathway;>>GnRH secretion
Human protein sequence Database
P01229
Mouse protein sequence database
O09108
Rat protein sequence database
P01230
Cellular localization
Secreted.
Tissue expression
Pituitary gland.
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