Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDKAL. AA range:10-59
Specificity
CDKAL1 Polyclonal Antibody detects endogenous levels of CDKAL1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010],
Function
cofactor:Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,similarity:Belongs to the methylthiotransferase family. CDKAL1 subfamily.,similarity:Contains 1 MTTase N-terminal domain.,similarity:Contains 1 TRAM domain.,
Protein name
Threonylcarbamoyladenosine tRNA methylthiotransferase
Other name
CDKAL1; Threonylcarbamoyladenosine tRNA methylthiotransferase; CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6)A37 methylthiotransferase
Human protein sequence Database
Q5VV42
Mouse protein sequence database
Q91WE6
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein . Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. .
Tissue expression
Expressed in pancreatic islets.
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