Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IDO2. AA range:101-150
Specificity
INDOL1 Polyclonal Antibody detects endogenous levels of INDOL1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011],
Function
tryptophan metabolic process, tryptophan catabolic process, cellular amino acid derivative metabolic process, biogenic amine metabolic process, indolalkylamine metabolic process, cellular amino acid catabolic process, aromatic amino acid family metabolic process, aromatic amino acid family catabolic process, amine catabolic process, organic acid catabolic process, aromatic compound catabolic process, tryptophan catabolic process to kynurenine, cellular amino acid derivative catabolic process, biogenic amine catabolic process, indole and derivative metabolic process, indole derivative metabolic process, indole derivative catabolic process, indolalkylamine catabolic process, carboxylic acid catabolic process, heterocycle catabolic process, oxidation reduction,
Protein name
Indoleamine 2,3-dioxygenase 2
Other name
IDO2; INDOL1; Indoleamine 2,3-dioxygenase 2; IDO-2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Fields
>>Tryptophan metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>African trypanosomiasis
Human protein sequence Database
Q6ZQW0
Mouse protein sequence database
Q8R0V5
Rat protein sequence database
Cellular localization
cytoplasm,cytosol,integral component of membrane,
Tissue expression
Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).
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